It was not immediately clear how many attackers were involved. La Vanguardia newspaper said one of the suspected perpetrators had been killed in a shootout with police on the outskirts of Barcelona.
Witnesses said the van zigzagged down one of Barcelona's busiest tourist avenues, Las Ramblas, mowing down pedestrians and leaving bodies strewn across the ground.
A government official in the region of Catalonia, which includes Barcelona, said that 80 people were injured.
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