The cartoonist, known as Luz, told French magazine Les Inrockuptibles that he is no longer interested in drawing cartoons that depict Prophet Muhammad.
"I will no longer draw the figure of Muhammad," Luz said. "It no longer interests me."
"I will not spend my lifetime drawing them," he added.
The magazine with a history of publishing derogatory depictions of Prophet Muhammad made headlines in January when a deadly attack targeted its Paris headquarters killing 12 people, including its editor and a number of prominent cartoonists.
Following the attack, Luz drew Charlie Hebdo`s front cover picture showing a cartoon resembling Prophet Muhammad holding a "Je Suis Charlie" (I Am Charlie) sign.
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