The violent day started in the morning when a 35-year-old man was shot near the Brewerytown neighborhood.
In the afternoon, a 26-year-old father was killed and his 17-year-old cousin was shot in the hip in the Nicetown neighborhood. Police said at least two gunmen were involved in the incident and 37 shells were found at the scene.
In a separate shooting, a 25-year-old man was shot multiple times and was taken to hospital in a critical condition. Police detained one person linked to the shooting. The fourth shooting involved a 27-year-old victim, who was rushed to hospital in critical condition with wounds to the stomach.
Finally after 9 p.m. (0100 GMT on Sunday), a sixth victim was shot 10 times in the hands, arms and legs and was taken to hospital in a stable condition.
More than 80 people were killed in Philadelphia this year, up 11 percent from the same period last year, local media reported.