Police in the southeastern city fired teargas and arrested several people after several hundred demonstrators started throwing objects, burning rubbish bins and trying to enter areas where protests have been banned.
Altogether about 2,000 protesters had gathered on the Allee Jean Jaures, a wide avenue in the city center and on nearby side streets.
Activist groups had said on social media networks that Toulouse would be the focus for the 22nd round of demonstrations, prompting city mayor Jean-Claude Moudenc to express concern ahead of Saturday’s protests.
Marches in Paris and elsewhere were largely peaceful by early afternoon, but the protests continue to put pressure on Macron. He has vowed to announce a series of measures aimed at easing discontent in the country.
The protests, named after the high-visibility safety jackets worn by demonstrators, began in November to oppose fuel tax increases.
However, the movement quickly morphed into a broader backlash against Macron’s government, despite a swift reversal of the tax hikes and other hurried measures worth more than 10 billion euros to boost purchasing power for lower-income voters.
In response to rioting that made parts of Paris resemble war zones, Macron launched a two-month “grand debat”, a sweeping consultation that included a series of town hall meetings across the country.
Macron is due to introduce specific measures early next week.
Outlining the findings of the debate initiative, Prime Minister Edouard Philippe said this week that it had highlighted demands including quicker tax cuts, action to address climate change and closer ties between Paris and the provinces.