Since first hitting screens in 2007, The Big Bang Theory has become one of the most successful comedies in TV history - winning seven Emmy Awards.
It initially centred around a group of awkward male scientists and their interactions with their new female neighbour.
The cast paid tribute to the show, with Johnny Galecki posting on Instagram.
Galecki, who played physicist Leonard Hofstadter, posted a video showing Big Bang Theory creator Chuck Lorre snapping the clapboard for the final take of the final live scene of the series.
In its review [contains spoilers], CNN said the series, "closed with a big dose of heart" while website Indiewire said the finale "delivers an ending true to itself".
One time child actress Mayim Bialik, who plays neuroscientist Amy Farrah Fowler added her voice, along with Jim Parsons, who posted a photo of the cast. Parsons has earned four Emmy wins and a Golden Globe for his portrayal of Sheldon Cooper, a theoretical physicist.
The cast were among the highest paid actors on television and last summer, Parsons reportedly walked away from a two-season deal worth around $50m (£39m).
In 2017, the primary cast took pay cuts in order to boost the wages of Rauch and Bialik, who were earning a fifth of their salary.
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