All westbound lanes of Interstate 64 in York County, Virginia, about 80 kilometers southeast of Richmond, remained closed Sunday afternoon as authorities worked at the scene of the pileup, which began shortly before 8 a.m. EST, the Virginia State Police said on Twitter.
Fog and icy conditions were present on the road at the time of the accident, police said in a tweet.
"#VSP investigation continues into 63-vehicle chain reax crashes," the police tweeted. "35 transported for treatment. No fatalities reported."
The injuries ranged from minor to life-threatening, the police tweeted.
Video footage of the scene showed a sea of cars that had collided with one another or the interstate barricade, some with their doors, trunks and bumpers mangled.
A representative for the state police could not immediately be reached for comment.
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