In a live TV broadcast, Akufo-Addo said, "The patient who tested positive for the COVID-19 disease on Thursday had severe underlying health conditions."
The other patients were doing very well and were being managed by health professionals, Akufo-Addo said.
The dead is a 61-year-old Lebanese trader who tested positive for COVID-19 in the country on Thursday, said Alexander Abban, deputy minister for health.
Ghana has recorded 21 confirmed cases of COVID-19 as of Saturday.