"This is a great celebration for Israel," he said on the tarmac at Ben Gurion airport, near Tel Aviv, as a fork-lift truck started unloading the cargo from a red and yellow DHL air freighter.
The shipment was the first of eight million doses ordered from pharmaceutical giant Pfizer and its partner BioNTech.
It came ahead of Hanukkah, the Jewish Festival of Lights, which begins on Thursday.
"The end is in sight," Netanyahu said about the disease which has infected 348,948 Israelis, 2,932 of them fatally, according to a Wednesday update.
"What is important to me is that Israeli citizens get vaccinated," he added.
"I want to serve as an example to them and I intend to be the first to be injected with this vaccine in the state of Israel."
The Pfizer vaccine has yet to receive the necessary regulatory approvals for use in Israel but Netanyahu said he expected it to receive clearance "in the very near" future.
The results of third-phase clinical trials showed that the vaccine was 90 percent effective in preventing Covid-19 symptoms and did not produce adverse side effects among thousands of volunteers.
Britain started inoculating its citizens with the vaccine on Tuesday.
Israel has also contracted to buy six million Covid-19 vaccine doses from US biotech firm Moderna which are expected to be delivered in 2021, giving a total of 14 million shots for its populaton of nine million.
Both medications require two doses to be administered for optimal protection.
The Pfizer vaccine needs to be stored at the ultra-low temperature of -70 degrees Celsius (-94 Fahrenheit), posing handling and storage challenges.
More about:
