Madrid is now home to the largest outbreak, with 30 cases confirmed by PCR and a further 15 under investigation.
Madrid contact tracers have determined that a sauna was the focal point of monkeypox transmission, according to the region's health minister Enrique Ruiz Escudero. In Spain, the term sauna is often used to describe a gay bathhouse.
So far, all the cases in Spain have been detected in men. None of them have been hospitalized.
Madrid health authorities will investigate the sauna to learn more about how the virus may have been spread, Escudero added.
Leading Spanish daily El Pais on Friday also quoted hospital sources who say more and more people are coming forward with compatible symptoms.
Within Spain, Andalusia and the Canary Islands are investigating a total of three cases.
On Friday, Portugal also confirmed another nine infections, bringing the total confirmed cases in the nation to 23, with more under investigation.
Portuguese health authorities call for people “presenting ulcerative lesions, rashes, palpable ganglia, possibly accompanied by fever, chills, headaches, muscle aches and tiredness" to seek medical attention, to avoid "direct physical contact with others" and sharing "clothing, towels, sheets and personal effects while symptoms or skin lesions are present at any stage."
The monkeypox virus was first detected spreading outside of Africa in the UK earlier this month. In total, Britain has confirmed 20 infections.
The virus is continuing to spread internationally, with several other countries like Italy, Sweden, the US, and Canada confirming their first cases in recent days.
