Slippery pavements, crippled train networks, treacherous roads and cancelled flights are among the problems workers are facing on Monday.
The US government in Washington, as well as many schools and businesses throughout the region, are shut.
As the clean up begins, at least 31 people have been left dead.
The fatalities were as a result of car accidents, carbon monoxide poisoning and heart attacks suffered while shovelling snow.
Many East Coast residents spent Sunday digging out their cars and clearing pathways of snow which reached about 3ft (91cm) in five states.
The storm, dubbed "Snowmageddon" and "Snowzilla", has weakened and headed into the Atlantic Ocean. It is expected to bring heavy rain and gale-force winds to the UK.
It affected some 85 million people, at one point cutting the power to 300,000 people. The heaviest fall was recorded in Glengary, West Virginia, which had 42in.
In New Jersey, residents are taking stock of damage left by severe flooding that was a result of the storm churning high surf.
Many homes were left partially submerged, but Governor Chris Christie said the flooding was not as bad as it could have been.
In New York City - which saw its second-highest snowfall since records began in 1869 - a travel ban that effectively shut the city down has now been lifted.
And all government-funded schools in the city are open today.
New York City Mayor Bill de Blasio urged people to leave their cars covered with snow all week, but he tweeted that the city was now "bouncing back".
US blizzard: Millions battle snow travel chaos
26 January 2016
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Millions of commuters across the eastern US are battling into work as transport systems struggle to recover from a huge blizzard.
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