Lebanese group Hezbollah`s Al Manar television reported the blast had occurred at a Syrian army checkpoint.
The death toll was expected to rise because of the number of people with serious injuries, the British-based Syrian Observatory for Human Rights said.
Multiple explosions in February killed scores of people in the Sayeda Zeinab area, home to Syria`s holiest Shi`ite Muslim shrine, in one of the bloodiest attacks there in Syria`s five-year conflict.
A suicide attack there less than a month earlier claimed by ultra-hardline Sunni Muslim group Islamic State killed 70 people.
Car bomb near Damascus kills six people: monitor
25 April 2016
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A car bomb on the outskirts of the Sayeda Zeinab district south of Damascus killed at least six people on Monday, a monitoring group said, the third bombing attack in the area this year.
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