The aircraft took off from the Charles de Gaulle Airport in Paris at 23:09 GMT, an official source told Egypt Air. It was headed to Cairo International Airport.
According to Sky News Arabia, the aircraft`s last appearance was above Greece.
Egypt Air said that the aeroplane disappeared from radar screens 10 minutes (80 miles) before entering Egyptian airspace.
According to an official source cited by the airline on Twitter, contact with the plane was lost at 02:45 Cairo time (00:45 GMT) on Thursday.
Egyptair stated that search and rescue team looking for the missing aeroplane. The airline company has formed an emergency operations centre to deal with the situation, media reported.
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