The mayor of one town told Italian radio that "half the town is gone".
In Rome, some buildings shook for 20 seconds, according to La Repubblica newspaper.
A family of four had been found under rubble in the town of Accumoli, the town`s mayor Stefano Petrucci told RAI TV.
Meanwhile police said two people had died in the nearby village of Pescara del Tronto, RAI reported.
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