SkyTG24 television said some dead were found inside the Hotel Rigopiano in the town of Farindola on the Gran Sasso mountain in the central Abruzzo region.
On its website, Italian news agency Ansa quoted the head of a rescue squad that reached the hotel as saying "there are many dead."
No further details were immediately available.
A spate of strong earthquakes hit central Italy on Wednesday.
Four magnitude 5.2 and higher quakes struck near the hill town of Amatrice, some 100 km (60 miles) northeast of Rome, in the space of four hours. Much of the area had already been abandoned after last year`s earthquakes.
More about:
