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12:19
The bus was in a collision with a lorry near Stammbach in north Bavaria.
Some passengers have grave injuries and there are fears that several others may have died. Several rescue helicopters joined emergency workers at the scene.
A police spokesperson told the DPA news agency: "Realistically we have to expect some fatalities."
Police have blocked the motorway as rescue efforts continue. It is not yet clear what caused the collision.
A police spokesman told German news channel n-tv that there were good medical facilities in Bayreuth, not far from the crash site.
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