His departure comes less than three months after a Han Solo spin-off film also lost its directors.
Phil Lord and Christopher Miller were replaced by Ron Howard.
On Tuesday, a statement on the Star Wars website said: "Lucasfilm and Colin Trevorrow have mutually chosen to part ways on Star Wars: Episode IX.
"Colin has been a wonderful collaborator throughout the development process, but we have all come to the conclusion that our visions for the project differ. We wish Colin the best and will be sharing more information about the film soon."
British writer Jack Thorne - who wrote the script for Harry Potter and the Cursed Child - is reported to be working on the screenplay for Episode IX.
Lucasfilm has a reputation for ruthlessness when it comes to hiring and firing directors. In 2015, Fantastic Four's Josh Trank was dropped from directing a standalone Star Wars story.
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