An unidentified body was found in a guest room and two people were injured, said Htay Lwin, a spokesman of hotel owner Htoo Group.
Authorities were investigating the cause of the fire and the cost of the damage was not immediately clear, he added.
The fire had been mostly extinguished by 7 a.m., and more than 140 guests were shifted to nearby hotels.
Htoo Group is chaired by business tycoon Tay Za, who, until last year, was on the list of United States sanctions for his close links to Myanmar’s former military regime.
Myanmar’s civilian-led government, helmed by Nobel laureate and former dissident Aung San Suu Kyi, is grappling with the aftermath of a harsh military crackdown that has driven out more than 500,000 of the country’s Rohingya Muslim minority.
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