Sohrab Qaderi, member of the local provincial council, said the attack appeared to have targeted a building of the department of refugee affairs. He said there had been at least three explosions.
There was no immediate word on casualties.
The blasts came amid a series of complex attacks that have hit Jalalabad in recent weeks, killing and wounding dozens of people.
There was no immediate claim of responsibility for Tuesday’s attack but most of the recent attacks have been claimed by militant group Islamic State, which has its main stronghold in Nangarhar province, on the border with Pakistan.
A roadside bomb hit a bus in the west of the country on Tuesday, killing as many as 11 people, officials said.
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