His wife reported him missing after a trip to China in late September.
French authorities have opened an investigation into the whereabouts of the head of Interpol, police sources told several news outlets on Friday.
Meng Hongwei, a Chinese national who was elected head of Interpol in 2016, traveled to China at the end of September and has not been heard from since, his wife told police.
Interpol's headquarters are in Lyon, in central France.
Meng served as Chinese Vice Minister of Public Security before he succeeded French policewoman Mireille Ballestrazzi, becoming the first Chinese official to hold the post.
At the time, human rights organizations such as Amnesty International expressed concerns that Beijing could use Interpol to arrest dissidents and refugees abroad.
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