Brazil's new far-right President Jair Bolsonaro will hold the first keynote speech of the four-day World Economic Forum annual meeting in the snowy mountains in the afternoon.
It is Bolsonaro's first international appearance since he was sworn in as president at the start of January. Although the controversial populist leader has already announced a plan to privatize infrastructure, it is still unclear whether he will really opt for ultra-liberal economic policies.
The Brazilian president takes the forum's keynote slot from U.S. President Donald Trump, who canceled his attendance to deal address a weekslong partial government shutdown.
British Prime Minister Theresa May, French President Emmanuel Macron and Zimbabwean President Emmerson Mnangagwa are also forgoing Davos this year, opting instead to address political crises at home.
"This year Davos is defined by those who do not attend," IHS Markit chief economist Nariman Behravesh told AFP.
Davos may be reverting to its roots as a purely business forum, "which is not necessarily a bad thing," he said.
Slowing global economic growth, populism, political tensions, trade wars and Britain's unclear path out of the European Union are among the main worries of the world's leaders, according to surveys and forecast published ahead of the Davos meeting.
This year's official theme is "Globalization 4.0" - a vision of an interconnected world that tackles the economic inequality that goes along with globalized trade and production.
But while the gathering high in the Swiss Alps is dedicated to networking and schmoozing, the International Monetary Fund started the week with a downbeat downgrade of its forecasts for global growth.
The IMF notably cited a U.S.-China trade war, and Brexit clouds surrounding Britain's divorce from the European Union.
But while growth is slowing, aid charity Oxfam warned the Davos elite that inequality around the world most certainly is not.
The wealth of the world's 26 richest people is now equivalent to that of the poorest half of humanity, Oxfam said, warning that such an imbalance was stoking popular anger and undermining democracies around the world.
Three of those billionaires are attending Davos -- Microsoft co-founder Bill Gates, China's richest man Jack Ma and Indian tycoon Mukesh Ambani.
The WEF week features an eclectic lineup of discussions devoted to issues such as mindful parenting in the digital age, chronic loneliness, and harnessing artificial intelligence without destroying jobs.