One man sustained serious injuries and was taken to hospital in Pamplona, while a second man was slightly gored by a bull, according to local health services.
Among those running with the bulls was Rick -- a visitor from Miami, United States -- who was taking part in his 18th run.
"It`s very hard to describe other than sheer, utter terror, exhilaration, like that. It happens so fast that you don`t have time to really think about it, you just have to do it. There`s no words to describe the feeling," he said.
Another runner from Santa Fe, New Mexico, was celebrating his 30th year at the San Fermin festival. Asked what made him keep coming back, he said: "First - fear, then second - joy. At the end mixed together. It`s just great. There`s nothing like running with the bulls in Pamplona," Robert Liam Kiely said.
The animals completed the 846-metre-long run in 2 minutes and 14 seconds.
Following the morning`s events, bull runners packed the bars and restaurants of Pamplona to reflect on the experience and count their blessings that they avoided being gored.
It was the first time that bulls from El Tajo and La Reina stockbreeders have run in the San Fermin festival.
Many Spanish towns hold festivals involving bulls during the summer. San Fermin is the most famous internationally and attracts thousands of revellers, many from abroad.
Its daily bull run starts at 8 a.m. (0600 GMT) and usually lasts between 3 and 5 minutes. There are eight runs in total.
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