The North Carolina Highway Patrol responded to the crash just after 2 p.m. (GMT-4) in Lee County.
The agency said the crash happened near the Sanford Raleigh Executive Airport.
A family of four was on board at the time of the crash, according to the state's highway patrol.
Three of the four occupants died on scene, and the fourth was transported to a local hospital, where they were pronounced deceased, officials said.
The family was identified as parents Travis Buchanan, 35, Candace Buchanan, 35, and their children, Aubrey Buchanan, 10, and Walker Buchanan, 9.
The Federal Aviation Administration and the National Transportation Safety Board are investigating the crash.
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