The box truck driver apparently was trying to make a U-turn, possibly changed his mind mid-turn and hit the two men, ages 66 and 79, who were on a sidewalk, officials said. The truck driver then hit the car carrying five people.
A homeland security employee happened to be at the scene and made a citizen's arrest, holding the driver until police arrived, official said.
Two pedestrians were taken to a trauma center, and one of them had life-threatening injuries, fire officials said. Five others with minor injuries were being evaluated at the scene, they said.
The crash was under investigation, and officials were asking the public to avoid the area.
No further details were available.
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