"We may be heading for another major financial crisis," he said.

Soros said that the rise of populism in Europe is a significant problem.

"The European Union is in an existential crisis. Everything that could go wrong has gone wrong," Soros said in his prepared remarks.

And he lamented the fact that since 2008, the European Union's austerity programs helped lead to the euro crisis. And that gave rise to anti-EU movements that are partly responsible for Brexit and the recent political turmoil in Italy.

"Many young people today regard the European Union as an enemy that has deprived them of jobs and a secure and promising future. Populist politicians exploited the resentments and formed anti-European parties and movements," Soros said.

Soros argued that the refugee crisis in Europe, "territorial disintegrations as exemplified by Brexit" and austerity are the three biggest challenges facing Europe. He warned that the Brexit "divorce will be a long process, probably taking more than five years."

But Soros is also worried about the fact that there is a growing divide between Europe and the United States with regards to Iran.

Soros said President Trump's decision to unilaterally withdraw from the nuclear arms treaty with Iran is "effectively destroying the transatlantic alliance."

Related: Soros has given $18 billion to his pro-democracy foundation

"The whole world has been shocked by President Trump's actions." Soros said.

"This development will put additional pressure of unpredictable force on an already beleaguered Europe. It is no longer a figure of speech to say that Europe is in existential danger; it is the harsh reality," he added.

Soros predicts that the termination of the deal with Iran "is bound to have a negative effect on the European economy and cause other dislocations" and noted that "the strength of the dollar is already precipitating a flight from emerging market currencies.

But Soros held out some hope that another global market and economic calamity could be avoided.

For example, he called for the EU, as opposed to just individual nations, to borrow more money to fund a "Marshall Plan" for Africa to deal with the refugee problem. Under the original Marshall Plan, the United States provided assistance to Europe to rebuild after World War II.

"The European Union has a high credit rating and its borrowing capacity is largely unused. When should that capacity be put to use if not in an existential crisis?" he asked.

Soros admitted that it won't be easy to get the many nations in the EU to agree on such a plan, but he added that "harsh reality may force member states to set aside their national interests in the interest of preserving the European Union."

But he added that "the economic stimulus of a Marshall Plan should kick in just at the right time."

And he continued to stress that "the economic case for remaining a member of the EU is strong, but it will take time for it to sink in" and added that the EU "needs to transform itself into an association that countries like Britain would want to join."

Soros is right. And that's clearly why the market was worried Tuesday.

The speech comes on a day when global financial markets were reeling because of concerns about the future of the EU after this past weekend's elections in Italy. Populists failed to form a government, which means that new elections will need to be held.

Europe has already dealt with Brexit. Now, Italexit is starting to once again trend on social media. And that's not a good sign.

CNNMoney 

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