US Federal Aviation Administration (FAA) officials said as cited by WAFB-TV that the plane was a twin-engine Cessna 421 light transport aircraft.
WAFB-TV cited FAA spokesman Lynn Lunsford as saying on Wednesday that "the plane had trouble shortly after taking off and crashed while trying to return to the field."
FAA is currently investigating the crash.
The identities of the two victims have not been released.
According to WDSU-TV, the Hammond Northshore Regional Airport currently hosts about 90 aircraft — general, corporate and military ones.
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