The Israeli leader has sought to project neutrality this time after perceptions arose that he favored Mitt Romney over President Barack Obama in 2012.
The one-on-one discussions will follow what was likely Netanyahu`s final meeting with Obama last week, capping what has been a sometimes rocky relationship between the leaders of the two allies.
The Obama administration has opposed Israel`s push to expand settlements in the West Bank while Netanyahu has been a leading critic of the U.S. nuclear agreement with Iran.
More recently, Netanyahu has urged Obama to avoid pushing for a Palestinian state in his final months in office.
Clinton has supported a negotiated two-state solution in the region, vowed to enforce the Iran nuclear agreement and help defend Israel`s security.
The former secretary of state suggested in an interview with Israel`s Channel 2 earlier this month that the Islamic State group was `rooting for Donald Trump`s victory` and he had helped strengthen the hands of extremists by his provocative statements about Muslims.
Trump has been a fierce critic of the Iran nuclear agreement and promised during a speech to AIPAC earlier this year that he would deepen ties between the two countries if he was elected president, adding the days of `treating Israel like a second-class citizen will end on day one.`
But he also raised eyebrows when he questioned Israel`s commitment to a peace deal last year and said he didn`t want to show any bias in favor of one side or the other.
The meetings will also come after the U.S. recently completed a 10-year, $38 billion military aid package for Israel.
Clinton said in a statement that it would help `solidify and chart a course for the U.S.-Israeli defense relationship in the 21st century as we face a range of common challenges.`
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